Bruce Beutler

Quick Facts

Full Name	Bruce Beutler
Occupation	Geneticist
Date Of Birth	Dec 29, 1957(1957-12-29)
Age	67
Birthplace	Chicago
Country	United States
Birth City	Illinois
Horoscope	Sagittarius

Bruce Beutler Biography

Bruce Beutler is one of the most popular and richest Geneticist who was born on December 29, 1957 in Chicago, Illinois, United States. Geneticist who was awarded the Nobel Prize for Physiology or Medicine for his research into the activation of the innate immune system. He is an active membre of both the United States National Academy of Sciences and the Institute of Medicine.

He as well as Chemist He and chemist Dudley R. Herschbach both became recipients of the Nobel Prize. both received Nobel Prizes. Nobel Prize.

Between 1959 and 1977, Beutler lived in Southern California. He received his secondary school education at Polytechnic School in Pasadena, California. He attended college at the University of California, San Diego, graduating at the age of 18 in 1976. He enrolled in medical school at the University of Chicago in 1977 and received his M.D. degree in 1981 at the age of 23.

Beutler is best known for his pioneering molecular and genetic studies of inflammation and innate immunity. He was the first to isolate mouse tumor necrosis factor-alpha (TNF), and to demonstrate the inflammatory potential of this cytokine, proving its important role in endotoxin-induced shock. Subsequently, he invented recombinant molecules expressly designed to neutralize TNF, fusing the binding portion of TNF receptor proteins to the heavy chain of an immunoglobulin molecule to force receptor dimerization. These molecules were later used extensively as the drug Etanercept in the treatment of rheumatoid arthritis, Crohn’s disease, psoriasis, and other forms of inflammation. Interested in the mechanism by which LPS activates mammalian immune cells, Beutler used TNF production as a phenotypic endpoint to identify the LPS receptor. Identification of the receptor hinged on the positional cloning of the mammalian Lps locus, which had been known since the 1960s as a key genetic determinant of all biological responses to LPS. Beutler thus discovered the key sensors of microbial infection in mammals, demonstrating that one of the mammalian Toll-like receptors, TLR4, acts as the membrane- spanning component of the mammalian LPS receptor complex. The TLRs (of which ten are now known to exist in humans) are now widely known to function in the perception of microbes, each detecting signature molecules that herald infection. These receptors also mediate severe illness, including shock and systemic inflammation as it occurs in the course of an infection. They are central to the pathogenesis of sterile inflammatory and autoimmune diseases such as systemic lupus erythematosus. The research on TLRs won him the Nobel Prize in 2011.

Three children are with him and his ex-wife Barbara Lanzl.

Bruce Beutler Net Worth

Bruce Beutler is one of the richest Geneticist from United States. According to our analysis, Wikipedia, Forbes & Business Insider, Bruce Beutler 's net worth $5 Million. (Last Update: December 11, 2023)

He earned his M.D. doctorate from University of Chicago when he was 23 years old.

He was Associate Investigator for He worked as an Assistant Investigator at the Howard Hughes Medical Institute. Medical Institute. He worked as an Assistant Investigator at the Howard Hughes Medical Institute. Medical Institute.

Bruce Alan Beutler (born December 29, 1957) is an American immunologist and geneticist. Together with Jules A. Hoffmann, he received one-half of the 2011 Nobel Prize in Physiology or Medicine, for “their discoveries concerning the activation of innate immunity” (the other half went to Ralph M. Steinman for “his discovery of the dendritic cell and its role in adaptive immunity”).

Height, Weight & Body Measurements

Bruce Beutler height Not available right now. Bruce weight Not Known & body measurements will update soon.

Who is Bruce Beutler Dating?

According to our records, Bruce Beutler married to Barbara Lanzl. As of December 1, 2023, Bruce Beutler’s is not dating anyone.

Relationships Record : We have no records of past relationships for Bruce Beutler. You may help us to build the dating records for Bruce Beutler!

In 2000, Beutler moved to The Scripps Research Institute in La Jolla, California, as a professor in the Department of Immunology. In 2007, he became chairman of the newly created Department of Genetics at Scripps Research. In 2011, Beutler returned to UT Southwestern Medical Center to become director of the Center for the Genetics of Host Defense.

Facts & Trivia

Bruce Ranked on the list of most popular Geneticist. Also ranked in the elit list of famous people born in United States. Bruce Beutler celebrates birthday on December 29 of every year.

Top Facts about Bruce Beutler

1. Bruce Beutler won the Nobel Prize in Physiology or Medicine in 2011.
2. He discovered key proteins involved in innate immunity.
3. Beutler’s research focuses on infectious diseases and cancer.
4. He is a member of the National Academy of Sciences.
5. Beutler received his MD from the University of Chicago.
6. He has published over 500 scientific papers.
7. Beutler is currently a professor at UT Southwestern Medical Center.
8. His work has led to new treatments for autoimmune disorders.
9. Beutler was born in Chicago, Illinois in 1957.
10. He co-founded a biotech company focused on immunotherapy research.

Why did Bruce Beutler win the Nobel Prize?

Beutler received the prize for his discovery of Toll-like receptor (TLR) 4 , the first-known mammalian receptor protein of the innate immune system. Beutler discovered the process by which mammals, including humans, detect invading microbes, a crucial initial step in mounting an immune response.

What did Bruce Beutler do?

Bruce Beutler, MD, discovered an important family of receptors that allow mammals to sense infections when they occur, triggering a powerful inflammatory response. For this work he received the 2011 Nobel Prize in Physiology or Medicine.