Peter J. Ratcliffe

Quick Facts

Full Name	Peter J. Ratcliffe
Occupation	University Teacher
Date Of Birth	May 14, 1954(1954-05-14)
Age	70
Birthplace	England
Country	United Kingdom
Horoscope	Taurus

Peter J. Ratcliffe Biography

Peter J. Ratcliffe is one of the most popular and richest University Teacher who was born on May 14, 1954 in England, United Kingdom. Ratcliffe was born in Lancashire on May 14, 1954 He was the son of William Ratcliffe and Alice Margaret Ratcliffe. Ratcliffe attended Lancaster Royal Grammar School from 1965 until 1972.

in 1989 Ratcliffe created a research lab within the Oxford the University’s Nuffield Department of Medicine to study the mechanisms of regulation of erythropoietin (EPO) which is a hormone produced by kidneys, which is that is responsible for stimulating growth of blood red cells. EPO is believed to be released by the kidneys as a result of low levels of oxygen, and Ratcliffe’s study sought to unravel the mechanisms behind how kidneys detect low oxygen levels (low oxygen level in blood) to stimulate EPO production. Based on his research, Ratcliffe discovered that the kidneys’ mRNA that was an element of the EPO production pathway in a position to detect hypoxia, was found in different organs in humans and animal, such as the brain, spleen and tests. The group discovered that the cells of these organs were able to turn on EPO production when deficient in oxygen. Furthermore, Ratcliffe was able to modify other cells by using the mRNA identified to confer these cells with oxygen- sensing abilities.

Building on these discoveries, the Ratcliffe group, along with joint studies with William Kaelin and Gregg Semenza, helped to uncover a detailed molecular chain of events that cells use to sense oxygen. A specific step identified was the binding of proteins expressed by the Von Hippel–Lindau tumor suppressor gene (VHL) to hypoxia-inducible factors (HIF), a transcription factor which trans-activates the EPO gene. Ratcliffe found that the VHL protein can bind a hydroxylated residues of HIF when oxygen is present at acceptable levels; the VHL protein then ubiquitylates the HIF protein which ultimately leads to the HIF protein’s destruction. When oxygen levels fall, oxygen-requiring HIF hydroxylase enzymes, PHD1, 2 and 3 no longer act and VHL does not bind HIF, allowing HIF to remain and activate the EPO gene. This is a process that takes minutes to complete allowing the body to react quickly to hypoxia.

He was knighted in the 2014 New Year Honours for services to clinical medicine.

Ratcliffe was then educated as a renal physician in Oxford University, focusing on the role of oxygenation in the renal system. He obtained a higher MD degree from the University of Cambridge in 1987.

Peter J. Ratcliffe Net Worth

Peter J. Ratcliffe is one of the richest University Teacher from United Kingdom. According to our analysis, Wikipedia, Forbes & Business Insider, Peter J. Ratcliffe 's net worth $5 Million. (Last Update: December 11, 2023)

Sir Peter John Ratcliffe, FRS, FMedSci (born 14 May 1954) is a British Nobel Laureate physician-scientist who is trained as a neurologist. He worked as a doctor in the John Radcliffe Hospital, Oxford as well as the Nuffield professor of clinical medicine as well as the director of the Nuffield Department of Clinical Medicine at the University of Oxford from 2004 until the year the year 2016. He has been a Fellow at Magdalen College, Oxford since 2004. In 2016 he was named Clinical Research Director of the Francis Crick Institute, retaining his post at Oxford as a member of the Ludwig Institute of Cancer Research and Director of the Target Discovery Institute, University of Oxford.

He was awarded an open scholarship for Gonville and Caius College, Cambridge in 1972, to pursue a degree in Medical Sciences in The University of Cambridge and then completed his MB BChir Medical doctorate with distinction from St Bartholomew’s Hospital Medical College in the year 1978.

In 1990, Ratcliffe received a Wellcome Trust Senior Fellowship to study cellular responses to hypoxia from low oxygen levels in the blood. From 1992 to 2004 he was Senior Research Fellow in Clinical Medicine at Jesus College, Oxford. In 2002, Ratcliffe was accepted into the Academy of Medical Sciences and was appointed the following year the Nuffield Professor and Head of the Nuffield Department of Clinical Medicine at Oxford.

Height, Weight & Body Measurements

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Who is Peter J. Ratcliffe Dating?

According to our records, Peter J. Ratcliffe married to Fiona Mary MacDougall. As of December 1, 2023, Peter J. Ratcliffe’s is not dating anyone.

Relationships Record : We have no records of past relationships for Peter J. Ratcliffe. You may help us to build the dating records for Peter J. Ratcliffe!

Facts & Trivia

Peter Ranked on the list of most popular University Teacher. Also ranked in the elit list of famous people born in United Kingdom. Peter J. Ratcliffe celebrates birthday on May 14 of every year.

What did Peter Ratcliffe discover?

William Kaelin, Peter Ratcliffe, and Gregg Semenza discovered how cells can sense and adapt to changing oxygen availability. During the 1990s they identified a molecular machinery that regulates the activity of genes in response to varying levels of oxygen.

Who is Sir Peter Ratcliffe?

Sir Peter John Ratcliffe, FRS, FMedSci (born 14 May 1954) is a British Nobel Laureate physician-scientist who is trained as a nephrologist.

Who is the governor in Pocahontas?

Pocahontas (1995) – David Ogden Stiers as Governor Ratcliffe, Wiggins – IMDb.

Was Ratcliffe a real person?

John Ratcliffe (born John Sicklemore; 1549 – December 1609) was an early Jamestown colonist, mariner and captain of Discovery , the smallest of three ships (the other two being The Susan Constant and The Godspeed) that sailed from the Kingdom of England on 19 December 1606, to English-claimed Virginia to found a colony, …

Who is Governor Ratcliffe based on?

Trivia. Unlike most of the other Disney animated villains, Ratcliffe is one of two villains based on an actual historical person , with the other being Prince John from Robin Hood. There is a foreshadowing of Ratcliffe’s character when he boards the ship in England.