Titia de Lange

Quick Facts

Full Name	Titia de Lange
Occupation	Geneticist
Date Of Birth	Nov 11, 1955(1955-11-11)
Age	69
Birthplace	Rotterdam
Country	Netherlands
Birth City	South Holland
Horoscope	Scorpio

Titia de Lange Biography

Titia de Lange is one of the most popular and richest Geneticist who was born on November 11, 1955 in Rotterdam, South Holland, Netherlands. Titia De Lange (born 11 November 1955 at Rotterdam) is the director of the Anderson Center for Cancer Research and as well as the Leon Hess professor and the director of the Laboratory Cell Biology and Genetics at Rockefeller University.

In Rockefeller University her research focused on identifying proteins related to the telomeres as well as their role in preventing telomeres from the processes that repair DNA. In her early years, she committed a lot of time and energy to identify the main proteins that make up human the telomeres. The year 1995 was the time she discovered and isolated the Telomeric repeat the binding protein one (TRF1). With the help from Bas van Steensel de Lange conducted various research on proteins that are associated with Telomeres. She discovered that TRF1 is essential in the control on the size of the telomeres. Her research concluded that TRF1 blocks the actions of the telomerase. Telomerase is an RNA-dependent DNA polymerase that is able to lengthen Telomeres and plays a vital role in maintaining Telomeric DNA. Telomerase is able to counteract the shrinking of telomeres which happens in the process of DNA replication. They also identified TRF2, a protein TRF2 and discovered that it hinders the end-to end fuse of telomeres in addition to having other functions. One of the major discoveries of Titia was her discovery of the t -loop-like structure of the telomeres she discovered in her working along with Jack Griffith. The structure was revealed by electron microscopy to show that telomeric DNA with linear structure can be transformed by TRF2 to form Duplex Loops (t loops). This design change allows TRF2 to lock up the ends of telomeres which protect telomeres from overhanging DNA strands. This safeguards against incorrect activate of checkpoints for DNA damage natural ends of chromosomes. Research has previously revealed that, in addition to protecting end chromosomes the telomeric complexes can also help cells to differentiate between random DNA breaks from natural ends of chromosomes.

De Lange is the recipient of several awards including the 2001 Paul Marks Prize for Cancer Research, the 2008 Massachusetts General Hospital Cancer Center Prize, the 2010 AACR Clowes Memorial Award, the 2011 Vanderbilt Prize in Biomedical Science, the 2011 Vilcek Prize in Biomedical Science, the 2013 Breakthrough Prize in Life Sciences, the 2014 Gairdner International Award, and the 2017 Rosenstiel Award.

In 2005, de Lange came to the crucial realization that six telomeric proteins form a dynamic protein complex, that she named shelterin, named for its function of protecting chromosome ends. The six shelterin subunits are: TRF1, TRF2, TIN2, Rap1, TPP1, and POT1. Shelterin subunits are not the only proteins that associate with telomeres but they differ from other proteins by meeting the criteria of not accumulating in areas beside chromosome ends, their function is limited to telomeres, and they are present at telomeres throughout the cell cycle. Shelterin allows for telomeres to be essentially hidden from the DNA damage surveillance, without its safeguarding chromosome ends are inappropriately processed by DNA repair pathways where the telomeres would be mistaken for damaged DNA.

Titia de Lange studied at Titia de Lange’s University of Amsterdam where she earned her bachelor’s and master’s degrees in biochemistry. She also obtained the Ph.D. from the University of Amsterdam during her time in the Netherlands Cancer Institute. In 1985, she was offered the postdoctoral fellowship with the University of California, San Francisco. In the year 1990, de Lange started her own lab at Rockefeller University. It is where she is an Leon Hess Professor as well as the Director of the Anderson Center for Cancer Research at Rockefeller University. She received the Breakthrough Prize in Life Sciences in 2013 for her work on telomeres. She has revealed how they shield the chromosome’s ends and play a involvement in the process of generating instability in the genome in cancer through studying the molecular complex that binds the strands of DNA and shields the strands. Alongside making progress in uncovering the DNA structure Her research could have implications for understanding the aging process and cancer.

Titia de Lange Net Worth

Titia de Lange is one of the richest Geneticist from Netherlands. According to our analysis, Wikipedia, Forbes & Business Insider, Titia de Lange 's net worth $5 Million. (Last Update: December 11, 2023)

De Lange obtained her Masters in “Chromatin structure of the human ss-globin gene locus” at the University of Amsterdam in 1981 and then her PhD at the same university in 1985 along with Piet Borst studying the surface antigen genes of trypanosomes. In 1985, she was a part of Harold Varmus’s lab at University of California, San Francisco. Since 1990, she has held an appointment as a professor at Rockefeller University. 2011 was the year that de Lange received the Vilcek Prize in Biomedical Science. In 2013, she was awarded the Breakthrough Prize in Life Sciences which was worth $3 million for her work on the telomeres.

De Lange started to gain an interest in telomeres as she was completing her Ph.D. at the Netherlands Cancer Institute. Telomeres progressively became the main subject of her studies. Following her Ph.D. in 1985, de Lange completed a postdoctoral position with the University of California, San Francisco in Harold Varmus’s Lab from 1985 until 1990. While within UCSF, de Lange continued her research on the telomeres. de Lange discovered that sperm cells have telomeres several thousand times larger than cells of the somatic. She also discovered that tumor cells have telomeres that are significantly shorter. This research is significant in establishing the importance of telomeres both in the process of aging and also in cancer. Telomeres are nucleotide sequences that repeat on the ends of chromosomes. They protect against damage to DNA. The sequence of nucleotides in telomeres is TTAGGG. As you age, the telomeres shrink gradually with each cycle of DNA replication because there isn’t a complete DNA sequence is replicated. The ends of chromosomes are at risk due to different pathways, including DNA damage signaling pathways that involve ATM or ATR kinase and Double-strand-break repair mechanisms. non-homologous end joining, or homology-directed repair.

In 2000 she became correspondent of the Royal Netherlands Academy of Arts and Sciences.

Height, Weight & Body Measurements

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Who is Titia de Lange Dating?

According to our records, Titia de Lange is possibily single & has not been previously engaged. As of December 1, 2023, Titia de Lange’s is not dating anyone.

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Facts & Trivia

Titia Ranked on the list of most popular Geneticist. Also ranked in the elit list of famous people born in Netherlands. Titia de Lange celebrates birthday on November 11 of every year.