Ronald Vale

Quick Facts

Full Name	Ronald Vale
Occupation	Biochemist
Date Of Birth	Jan 11, 1959(1959-01-11)
Age	65
Birthplace	Hollywood
Country	United States
Birth City	California
Horoscope	Capricorn

Ronald Vale Biography

Ronald Vale is one of the most popular and richest Biochemist who was born on January 11, 1959 in Hollywood, California, United States. Ronald David Vale, born 1959, is a biochemist as well as a cell biologist. He is a professor at University of California, San Francisco’s Department of Cellular and Molecular Pharmacology. His research focuses on motor proteins, especially kinesins and dynein. He received the Canada Gairdner International Award for Biomedical Research in 2019 and the Shaw Prize in Life Science and Medicine in 2017. In addition, he was awarded the Albert Lasker Award for Basic Medical Research in 2012. Along with James Spudich and Michael Sheetz, he was also presented the Albert Lasker Award for Basic Medical Research in 2012. He is a Fellow of the American Academy of Arts and Sciences and an Associate of the National Academy of Sciences. In 2012, he was president of American Society for Cell Biology. Since 1995, he has been an investigator at Howard Hughes Medical Institute. Vale was appointed executive director of Janelia Research Campus in 2019 and vice president of HHMI.

Vale and Sheetz teamed with Bruce Schnapp, Thomas J. Reese, at the Marine Biological Laboratory. They discovered that membrane organelle transport was bidirectionally carried on microtubules, not as Vale originally believed. Further, Vale demonstrated that purified organelles rarely move on microtubules by themselves. However, movement was detected after adding the cytosol. The cytosol caused microtubules translocate along a surface of glass, which Vale discovered by serendipitous chance. He also found that microtubules moved along cytosol-coated beads. These two phenomena allowed for the development of in vitro assays for microtubule-based motility. Vale, Sheetz, and Reese identified the dominant motor protein of the cytosol in 1985 and named it “kinesin.” They found that kinesin moved only in one direction to the plus ends microtubules, while a second motor (later identified as dynein) moved in the other direction. In 1985, five papers were published the results of Vale’s and his colleagues on axonal transportation.

Vale did not finish his MD, and joined the University of California, San Francisco as an assistant professor in 1986. He was promoted to associate professor in 1992 and then to full professor in 1994. In 1989, Vale, with Jonathan Howard and A. James Hudspeth developed a single molecular assay for kinesin. In 1991, he discovered the first protein that severed microtubules and later purified and named it katanin. In 1996, Vale and colleagues solved the crystal structure of the kinesin motor domain. and discovered unexpectedly that it is structurally similar to myosin. In that same year, working with Toshio Yanagida, Vale developed a single-molecule fluorescence assay for kinesin. In 1999, using various techniques, Vale and co-workers developed a mechanical model for how the two motor domains of the kinesin dimer walk in a “hand-over-hand” model along a microtubule.

Since 2003, Vale has focused on dynein, a motor protein discovered by Ian R. Gibbons in 1965. Although its discovery occurred 20 years before kinesin, its large size hampered its investigation. In 2006, Vale’s laboratory prepared recombinant dynein from yeast, and elucidated how it walked on microtubules using single-molecule microscopy. He then worked with Gibbons to determine the structure of the dynein microtubule-binding domain. His team also solved the structure of the dynein motor domain. Vale has extended his research to other fields, including T-cell signalling and RNA biology.

As a graduate student working on Nerve Growth Factor (NGF) receptors, Vale became curious about the mechanisms of how receptors and other molecules move in nerve axons. The research of James Spudich and Michael Sheetz, who used a video camera mounted on a microscope to record myosin-coated beads traveling along actin filaments, attracted his attention. Vale and Sheetz set out to determine if the movement of myosin onto actin was responsible for organelle transport in the axons. They used the squid giant as a model. Shooter approved that they go to the Marine Biological Laboratory, as no squid had been caught at Stanford’s Hopkins Marine Station in 1983.

Ronald Vale Net Worth

Ronald Vale is one of the richest Biochemist from United States. According to our analysis, Wikipedia, Forbes & Business Insider, Ronald Vale 's net worth $5 Million. (Last Update: December 11, 2023)

Eric Shooter supervised Vale as he completed a Stanford University MD/PhD in

1980. He studied the nerve growth receptor, also known as the neurotrophic factors receptor.

Vale is a first generation university student. He was a first-generation university student and enrolled at the College of Creative Studies, University of California Santa Barbara in 1980 to earn a bachelor’s in biology and chemistry. During his studies, he worked first at UCLA’s laboratory of C. Fred Fox, then at Duke University’s Robert Lefkowitz group. He was awarded two articles in 1984 and 1982.

Vale obtained his PhD in neuroscience in 1985. He then spent one year as an NIH staff scientist in Tom Reese’s laboratory at the Marine Biological Laboratory at Woods Hole, MA.

Height, Weight & Body Measurements

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Who is Ronald Vale Dating?

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Facts & Trivia

Ronald Ranked on the list of most popular Biochemist. Also ranked in the elit list of famous people born in United States. Ronald Vale celebrates birthday on January 11 of every year.