Gary Ruvkun

Quick Facts

Full Name	Gary Ruvkun
Occupation	Geneticist
Date Of Birth	Mar 26, 1952(1952-03-26)
Age	72
Country	United States
Horoscope	Aries

Gary Ruvkun Biography

Gary Ruvkun is one of the most popular and richest Geneticist who was born on March 26, 1952 in United States.

Ruvkun obtained his undergraduate degree in 1973 at the University of California, Berkeley. His PhD work was done at Harvard University in the laboratory of Frederick M. Ausubel, where he investigated bacterial nitrogen fixation genes. Ruvkun completed post-doctoral studies with Robert Horvitz at the Massachusetts Institute of Technology (MIT) and Walter Gilbert of Harvard.

Ruvkun’s research revealed that the miRNA lin-4, a 22 nucleotide regulatory RNA discovered in 1992 by Victor Ambros’ lab, regulates its target mRNA lin-14 by forming imperfect RNA duplexes to down-regulate translation. The first indication that the key regulatory element of the lin-14 gene recognized by the lin-4 gene product was in the lin-14 3’ untranslated region came from the analysis of lin-14 gain-of-function mutations which showed that they are deletions of conserved elements in the lin-14 3’ untranslated region. Deletion of these elements relieves the normal late stage-specific repression of LIN-14 protein production, and lin-4 is necessary for that repression by the normal lin-14 3′ untranslated region. In a key breakthrough, the Ambros lab discovered that lin-4 encodes a very small RNA product, defining the 22 nucleotide miRNAs. When Ambros and Ruvkun compared the sequence of the lin-4 miRNA and the lin-14 3’ untranslated region, they discovered that the lin-4 RNA base pairs with conserved bulges and loops to the 3’ untranslated region of the lin-14 target mRNA, and that the lin-14 gain of function mutations delete these lin-4 complementary sites to relieve the normal repression of translation by lin-4. In addition, they showed that the lin-14 3′ untranslated region could confer this lin-4-dependent translational repression on unrelated mRNAs by creating chimeric mRNAs that were lin-4-responsive. In 1993, Ruvkun reported in the journal Cell (journal) on the regulation of lin-14 by lin-4. In the same issue of Cell, Victor Ambros described the regulatory product of lin-4 as a small RNA These papers revealed a new world of RNA regulation at an unprecedented small size scale, and the mechanism of that regulation. Together, this research is now recognized as the first description of microRNAs and the mechanism by which partially base-paired miRNA::mRNA duplexes inhibit translation.

Gary Ruvkun Net Worth

Gary Ruvkun is one of the richest Geneticist from United States. According to our analysis, Wikipedia, Forbes & Business Insider, Gary Ruvkun 's net worth $5 Million. (Last Update: December 11, 2023)

Gary Bruce Ruvkun (born 26 March 1952, Berkeley, California) is an American molecular biologist at Massachusetts General Hospital and professor of genetics at Harvard Medical School in Boston. Ruvkun discovered the mechanism by which lin-4, the first microRNA (miRNA) discovered by Victor Ambros, regulates the translation of target messenger RNAs via imperfect base-pairing to those targets, and discovered the second miRNA, let-7, and that it is conserved across animal phylogeny, including in humans. These miRNA discoveries revealed a new world of RNA regulation at an unprecedented small size scale, and the mechanism of that regulation. Ruvkun also discovered many features of insulin-like signaling in the regulation of aging and metabolism. He was elected a Member of the American Philosophical Society in 2019.

Height, Weight & Body Measurements

Gary Ruvkun height Not available right now. Gene weight Not Known & body measurements will update soon.

Who is Gary Ruvkun Dating?

According to our records, Gary Ruvkun is possibily single & has not been previously engaged. As of December 1, 2023, Gary Ruvkun’s is not dating anyone.

Relationships Record : We have no records of past relationships for Gary Ruvkun. You may help us to build the dating records for Gary Ruvkun!

In 2019, Ruvkun, together with Chris Carr, Mike Finney and Maria Zuber, is working to have NASA send a DNA sequencer to Mars to search for life there in the hope that evidence will be uncovered that life did not arise originally on Earth, but elsewhere in the universe.

Facts & Trivia

Gene Ranked on the list of most popular Geneticist. Also ranked in the elit list of famous people born in United States. Gary Ruvkun celebrates birthday on March 26 of every year.