Charles David Allis

Quick Facts

Full Name	Charles David Allis
Occupation	Molecular Biologist
Date Of Birth	Mar 22, 1951(1951-03-22)
Age	73
Birthplace	Cincinnati
Country	United States
Birth City	Ohio
Horoscope	Aries

Charles David Allis Biography

Charles David Allis is one of the most popular and richest Molecular Biologist who was born on March 22, 1951 in Cincinnati, Ohio, United States. Charles David Allis (born March 22, 1951) is an American molecular biologist, and is currently the Joy and Jack Fishman Professor and head of the Laboratory of Chromatin Biology and Epigenetics at The Rockefeller University.

Charles David Allis Net Worth

Charles David Allis is one of the richest Molecular Biologist from United States. According to our analysis, Wikipedia, Forbes & Business Insider, Charles David Allis 's net worth $5 Million. (Last Update: December 11, 2023)

In pursuit of understanding the DNA-histone protein complex and the intricate system which allows for gene activation, the Allis lab focuses on chromatin signaling via histone modifications – acetylation, methylation and phosphorylation. David Allis is best known for deciphering regulatory mechanisms that impinge upon the fundamental repeating unit of chromatin. Allis was not the first one to recognize histone acetyltransferase activity (Cano, A. & Pestana, A. Purification and properties of a histone acetyltransferase from Artemia salina, highly efficient with H1 histone. Eur. J. Biochem. 97, 65–72 (1979)), nor its role in the regulation of gene expression (Allfrey, V. G. (1970) Fed. Proc. 29, 1447- 1460.) but he sparked renewed interest in chromatin function. Histone acetylation as well as other modifications (methylation, phosphorilation, ubiquitination) may frame the “Histone Code” or “Epigenetic Code.” While the DNA code is responsible for the sequence of RNA’s and proteins, the Histone Code may ultimately be responsible for the epigenetic regulation of this genetic information. Allis discovered the critical link, through histone acetyltransferase-containing transcriptional coactivators, between targeted histone acetylation and gene- specific transcriptional activation. In further studies, he linked histone phosphorylation events to mitosis and mitogen action, established a synergy between histone phosphorylation and acetylation events and elaborated the ‘histone code hypothesis’ (and extensions thereof), one of the most highly cited theories governing epigenetics.

Recent studies suggest a new model wherein histone mutations (‘oncohistones’) represent a novel and previously unrecognized mechanism to alter epigenetic states in a variety of pathologies through inhibition of a wide range of histone methyltransferases. In turn, oncohistone mutations exert their oncogenic effect by reprogramming the cellular epigenome and transcriptome, thereby disrupting the highly coordinated epigenetic programs required for cell-specific differentiation. Implications of this research for human biology and human disease, notably cancer, are far-reaching and continuing at a remarkable pace.

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Facts & Trivia

Charles Ranked on the list of most popular Molecular Biologist. Also ranked in the elit list of famous people born in United States. Charles David Allis celebrates birthday on March 22 of every year.